Abstract

ANTIPLATELET AGENTS: A REVIEW

Diksha Dhiman*, Archana Chaudhary, Vinay Pandit and CPS Verma

ABSTRACT

Platelet plays a very important role in the physiological haemostasis and thrombus formation. Platelet aggregation is the key factor in the development of arterial ischaemic events, which includes coronary artery diseaseand peripheral arterial disease. As such, antiplatelet therapy plays a vital role in preventing the recurrent events in the individuals who are affected by one of the above conditions. Until recently, the use of antiplatelet therapy was limited to aspirin and clopidogrel. However, this has changed drastically with the advent of newer and more potent agents, prasugrel and ticagrelor and alsothe glycoprotein IIb/IIIa antagonists. Antiplatelet therapies are essential tool which reduces the risk of developing apparent atherothromboticdisease and plays a significant role in the therapy of patients who are dealing withcardiovascular and peripheral artery diseases. The novel antiplatelet therapies focus on additional receptor which prolongs the antiplatelet efficacy thereby preserving thehaemostasis, and hence improves patients with atherothrombotic diseases.

Keywords: Antiplatelet agent, Platelets, aspirin, clopidogrel, platelets, prasugrel, ticagrel.