Abstract

A REVIEW OF PHYTOCHEMISTRY OF HELICHRYSUM WITH INHIBITION OF OXIDATIVE STRESS PROPERTIES AND OTHER RELATED BIOLOGICAL IMPORTANCE

Popoola Olugbenga Kayode*

ABSTRACT

The diversity present in biological activities and the medicinal significance of natural products provide a renewed interest in the use of natural compounds and, more importantly, their role as a basis for drug development. Advancements in the field of natural product connect primarily the ethno-medicinal information of the medicinal plants to the chemical, biological and pharmacological leads in medicine. This review focuses understanding about the specific chemical profile (most especially polyphenolics such as flavonoids) of Helichrysum, as an icon of recognition in alleviating cellular oxidative stress and other related human ailments. Due to experiences in the field of natural products chemistry, this review also displayed chemical structures of some notable polyphenols and other related compounds previously isolated from the genus that displayed potent antioxidant activities and provide basis for structural-activity-relationship and notable biological specificity therein. It can also be a valuable reference point for the researchers in natural product, sourcing for notable compounds (including their analogues) isolated from this genus and their biological importance. The conclusion described directions for future Helichrysum research to establish its mechanistic mode of biological specificity displayed by individual compounds in relation to their respective chemical structures and pivot information from the drug discovery point of view as possible raw materials for cosmetic and pharmaceutics agent in near future.

Keywords: Helichrysum, Natural Products, Antioxidant, Polyphenols, Cosmetics, Pharmaceutics.