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FORMULATION, OPTIMIZATION AND EVALUATION OF ANTI-ALLERGIC TABLET
Shubham M. Shende*, Surendra Dangi, Prem Samundare, Neeraj Upmanyu and Rakesh Raj
ABSTRACT
Aim: The main objective of the present work is formulate and optimizes the combination anti-allergic tablet of Cetirizine and curcumin. Rosemary extract is used to enhance the therapeutic effect in both acute and chronic cases. Material and Method: The Antiallergic tablet is formulate by the wet granulation method using various excipients like HPMC, lactose starch, Polyethylene glycol in different concentrations for optimization of excipients. Rosemary extract contains ursolic acid and rosmarinic acid. Which is shows anti-inflammatory and Antiallergic activity so that it is used in the combination of Cetirizine and curcumin. Result and Discussion: FTIR spectra of API and combined with excipients showed no change in the peak indicating the absence of interaction, The prepared formulation Keywords: Cetirizine, Curcumin, Rosemary extract, Antiallergic tablet, FTIR. [Download Article] [Download Certifiate] |