Abstract

HEPATOPROTECTIVE MEDICATION FOR LIVER INJURY

Savita Mishra, Vidhu Aeri and Deepshikha Pande Katare*

ABSTRACT

Hepatic disorder is leading cause for withdrawals of drugs from market. Resent research on hepatotoxicity suggest that reactive secondary metabolites of drug, xenobiotics, excessive alcohol consumption and some disease conditions are responsible for liver injury. These compounds directly affect mitochondrial permeability transitional pore, mitochondrial respiratory chain, cytochromes P-450, and glutathione S-acyltransferases etc. Synthetic drugs for treatment of liver injury can further cause liver damage, so herbal medication is the only way to cure hepatic injury. Various plant extracts and ployherbal medications have been clinically approved for their potent hepatoprotective activity. These review papers focus on cause hepatotoxicity by various toxic compounds and their cure by herbal medication. This review summarizes mechanism of hepatotoxicity by various toxins and also provides data on hepatoprotective plants with their phytoconstituents which can be further useful for isolation of novel phytochemical constituents form plants for the treatment of liver injury.

Keywords: hepatoprotective plants; liver disease; mitochondrial permeability transitional pore opening; mitocondrial dysfunction; polyherbal medication.