Abstract

A REVIEW ARTICLE ON NOVEL DRUG DELIVERY SYSTEM; MICROSPHERE

Priya Katiyar*, Sonam Singh Parmar, Sunil Kumar, Shubham Tripathi and Harshita Gupta

ABSTRACT

Microspheres having free flowing powder characteristics, which are consisting of synthetic polymers and proteins. These are biodegradable in nature having particle size less than 200um. Floating microspheres are gastro-retentive drug delivery systems based on non-effervescent approach. Hollow microspheres are in strict sense, spherical empty particles without core. These microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, ideally having a size less than 200 micrometer. Solid biodegradable microspheres incorporating a drug dispersed or dissolved throughout particle matrix have the potential for controlled release of drugs. When microspheres come in contact with gastric fluid the gel formers, polysaccharides, and polymers hydrate to form a colloidal gel barrier that controls the rate of fluid penetration into the device and consequent drug release. As the exterior surface of the dosage form dissolves, the gel layer is maintained by the hydration of the adjacent hydrocolloid layer. The air trapped by the swollen polymer lowers the density and confers buoyancy to the microspheres. However, a minimal gastric content needed to allow proper achievement of buoyancy. Hollow microspheres of Acrylic resins, Eudragit, PMAA, Polyethylene oxide, and Cellulose acetate; Polystyrene floatable shells; Polycarbonate floating balloons and Gelucire floating microspheres are the recent developments. Microspheres are the multiarticulate drug delivery systems which are consisting from natural and synthetic material. Microsphere improves bioavailability, stability and target the drug to specific site at predetermined rate. types of microspheres are bio adhesive, floating, radioactive, polymeric and biodegradable microspheres. Microspheres are particularly used in novel drug delivery system.

Keywords: Microsphere, NDDS, advantages, types, method of preparations.