Abstract

ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF FERONIA LIMONIA (L.) LEAVES

Smita Khare*, Prabhat Khare, Dr. S K Jain

ABSTRACT

The study aimed to access the anti-inflammatory effect of Feronia limonia (FL, leaves of Feronia limonia (L.) Swingle). The leaves of FL were extracted with 95% ethanol and the dried extract (FLE) was administered intragastically (i.g.) at 100, 200 and 400 mg/kg. The antiinflammatory effect was evaluated in two experimental models. Pretreatment with a single dose of FLE produced significant dose dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema. In a 7-day study, daily administration of FLE suppressed cotton pallet-induced rat granuloma formation. In addition, single dose of FLE at 2g/kg body weight produce no observable acute toxicity in mice within seven days. These results demonstrate that FLE possess anti-inflammatory and has no obvious acute toxicity.

Keywords: Feronia limonia (FL), Feronia limonia Extract (FLE), anti-inflammatory effects, edema, granuloma.