Abstract

MOUTH DISSOLVING FILM- A NOVEL DRUG DELEVERY SYSTEM

Ashish Kumar Sharma*, Dilip Agarwal, Amit Jain, Rakesh Goyal, Ashok Kumar Sharma and Satendra Dube

ABSTRACT

Mouth dissolving film is the most advanced oral solid dosage form because of its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a moment when placed in mouth without taking water or chewing. This dosage form allows the medication to bypass the first pass metabolism so bioavailability of medication is also improved .Mouth dissolving film has potential to enhance onset of action lower the dosing and eliminate the fear of chocking. Development of mouth dissolving films involves both the visual and performance characteristics as plasticized hydrocolloids, API taste masking agents are being laminated by solvent casting and semisolid casting method. Solvent casting method being the foremost preferred method over other methods because it offers great uniformity of thickness and films prepared having fine glossy look and better physical properties. Mouth dissolving films are evaluated for its various parameters like thickness, property like folding endurance, disintegration and dissolution time. This review gives a concept about formulation techniques, evaluation parameters, overview on packaging and a few available marketed products of mouth dissolving films. Keywords: MDF, solvent, solvent casting method, fast disintegration, FPM.

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