Abstract

INVESTIGATION OF RELEASE RETARDANT PROPERTY AND ANTI-DIABETIC ACTIVITY OF TAMARINDUS INDICA AND ARTOCARPUS HETEROPHYLLUS SEED POLYSACCHARIDES

Sri Durga Devi Nagarajan*, Nandhini Devi Ganesan, Christopher Vimalson D., Sanjith Kumar Mary Mallika Raja, Surya Kala Nithiananthan, Kamali Kanniyakumar, Keerthana Nakka

ABSTRACT

The use of plant products is being largely preferred over synthetic products in the development of drugs as it is cost-efficient, easily accessible, eco-friendly and has a lower toxicity index. In the present study, an anti-diabetic tablet by direct compression technique was developed using Tamarind seed polysaccharide (Tamarindus indica) and Jackfruit seed polysaccharide (Artocarpus heterophyllus) to study their synergistic anti-diabetic activity using glimepiride as the model drug. The jackfruit seed based formulation showed in-vitro drug release profiles similar to the marketed formulation. Five kinetic models were used to analyze and determine the kinetics of drug release. Kinetic modeling of the in-vitro drug release data affirmed that the mechanism by which the drugs were released in these formulations was diffusion. The alpha-amylase inhibition test was performed for both the formulations and inhibition was observed. Percentage of amylase inhibition in jack fruit seed based formulation was higher when compared to that of the tamarind seed based formulation. Thus, both the tamarind seed polysaccharide and Jackfruit seed polysaccharide based formulations under investigation can be used in combination with synthetic drugs to reduce the dosage and toxicity.

Keywords: Tamarind seed polysaccharide, Jackfruit seed polysaccharide, Amylase inhibition, Direct compression.