Abstract

IMPROVEMENT OF DISSOLUTION RATE BY PREPARATION OF ETODOLAC SOLID DISPERSIONS

Addanki Anusha*, B. Veer Kumar, B. Prashanth, G. Vinay and H. Vinod Kumar

ABSTRACT

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties belonging to BCS class II drug and is practically water insoluble drug. An approach was made to enhance the dissolution rate of etodolac by preparing solid dispersions by using two different techniques i.e., solvent evaporation and kneading methods. Three different polymers like PVP K-30, PEG 6000 and polaxomer by varying the concentration ratios from (1:1 to 1:3) were used. The percentage release of Etodolac from various solid dispersions was determined from in vitro dissolution studies by using USP dissolution type II apparatus. The dissolution study results revealed that there was a considerable increase in solubility of all solid dispersions in comparison with the pure drug. The results indicated that 97.2% drug release was seen at 120 minutes. The optimized result was seen in (1:3) ratio of etodolac with polaxomer solid dispersion prepared by kneading method. Poloxamer is a group of block copolymer non-ionic surfactants, have attracted considerable attention for application in preparation of solid dispersions.

Keywords: Etodolac, Solid Dispersion, Polaxomer, Solvent Evaporation, Kneading method.