Abstract

DEVELOPMENT AND EVALUATION OF NANO-FIBER PATCH FOR SUSTAINED DRUG RELEASE FROM ELECTROSPUN NANOFIBERS

Safdar Hussain*

ABSTRACT

In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate as model drugs. The nano-fibers was prepared by electrospinning technique and was characterized on the basis of fiber diameter, morphology, folding endurance, pH of patch, wetting time, weight uniformity, and drug release behavior, etc. Topical administration for ocular therapeutics is ideal because of smaller doses required compared to the systemic use, its rapid onset of action. The specific aim of designing a therapeutic system is to achieve an optimal concentration of a drug at the active site for the appropriate duration. Ideal ophthalmic drug delivery must be able to sustain the drug release and to remain in the vicinity of front of the eye for prolong period of time. In this present investigation formed nanofibers are capable of providing sustained release of drug was prepared using polyvinyl alcohol. In vitro release of pure drug shown 45% release within 24 hours. Formulation displayed a sustained release pattern of Timolol Maleate. F10 is selected for in-vitro release study and was found to be more as compared to pure drug that showed that the formulation could enhance the drug delivery in the providing dosage form. From the in-vitro drug release study it was found that F10 formulation showed higher drug release as compared to pure drug.

Keywords: Nano-fiber patch, Drug Content, pH of the patch, folding endurance, In-vitro drug release study.