Abstract

SYNTHESIS & ANTI-INFLAMMATORY ACTIVITY OF SOME NOVEL PYRAZOLE DERIVATIVES

Priya Mishra, *Piyush Yadav, Braj Nandan Kishor and Suraj Mishra

ABSTRACT

In the current study we have made an attempt to synthesize eight novel pyrazole derivatives (3a-h) and evaluate them for anti-inflammatory activity using Carrageenan-induced rat paw edema method. In the first step, we synthesized substituted acetophenone phenyl hydrozone (1a-h) by using phenyl hydrazine and substituted acetophenone in the presence of acetic acid and H 2O.[1] The substituted acetophenone phenyl hydrozone (1a-h) was further reacted with Vilsmeier-Hack reagent (DMF-POCl3) at 0-5 0C to afforded 1,3-substituted diphenyl-1H-pyrazole-4-carbaldehyde.[2] The compound (2) was allowed to react with various substituted amines gave final pyrazole derivative(3a-3h). The structure of final Compound has been confirmed on the basis of elemental analysis, FTIR, 1H NMR & C13 NMR. All the values of elemental analysis, FTIR, 1H NMR & C 13NMR were found to be prominent. The pharmacological screening by Carrageenan-induced rat paw edema method for anti-inflammatory activity. The synthesized compounds were found to be 3a, 3b, 3c,3d, 3e, 3f,3g, and 3h. The compound 3a and 3d were found to be the most potent compound with compare to standard drugs Diclofenac sodium.

Keywords: Vilsmeier-Hack reagents (DMF-POCl3), Pyrazole, Anti-inflammatory activity, Carrageenan-induced rat paw edema method.