Abstract

IN-VITRO ANTIDERMATOPHYTIC ACTIVITY OF LOW POLAR PETROLEUM ETHER AND INTER POLAR METHANOLIC LEAF EXTRACT OF SENNA TORA L.

Shivakumar Singh P and Vidyasagar GM*

ABSTRACT

The use of plant and its products has a long history that began with folk medicine and through the years has been incorporated into traditional and allopathic medicine. Plant extracts represent a continuous effort to find new compound against pathogens. Antimycotic activity of Petroleum ether and methanolic leaf soxhlet extracts of Senna tora (Ceasalpiniaceae) was evaluated against dermatophytic fungi namely, Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Microsporum gypseum, Candida albicans and bacteria like, Staphylococcus aureus, Psudomonas aeruginosa, Bacillus subtilis, Escherichia coli. The maximum activity was observed in methanolic extract when compared to petroleum ether extract. The minimum inhibitory concentration, minimum fungicidal concentration and minimum bactericidal concentration were determined against all the test strains in interpolar extract. Preliminary Phytochemical tests were carried out using both the crude extracts.This study provides a basis for the isolation, purification and structural elucidation of anti-dermatophytic compounds from the leaves of Senna tora.

Keywords: Antimycotic activity, 98% methanolic young leaf extract, Senna tora, MIC, MFC, MBC.