Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MICROSPHERES OF ACEBUTOLOL HYDROCHLORIDE

Madhurima S Chavan*, Dr Surajj Sarode, Prof. Sathe Bhushankumar,Dr. G P Vadnere

ABSTRACT

Acebutolol HCl is a cardio selective Beta Blocker, widely used in the management of hypertension. The micro particles can be prepared by using any one of the several techniques but choice of the technique mainly depends on the nature of the polymer used, the drug and the duration of the therapy. In the present paper, a sustained release Acebutolol HCl microspheres prepared by solvent evaporation method in which the different concentration ranges of Acebutolol HCl and ethyl cellulose polymer was taken. The reaction mechanism to form sustained release Acebutolol HCl microspheres were determined by optical microscopic method and scanning electron microscope (SEM). The particle size of Acebutolol ranged from 302 to 370 μm. The size of particle was observed to increase with increasing concentration. The present study shows a relatively simple method to design and develop sustained release Acebutolol microspheres and evaluation micromeritics property , invitro study and Drug release kinetics of Acebutolol HCl.

Keywords: Acebutolol HCl, Poly vinyl alcohol, Ethyl Cellulose, Dichloromethane, Solvent Evaporation