Abstract

IN- VITRO AND IN -VIVO HEPATOTOXICITY INDUCED MODEL

Sadhana N. Patil*, Snehal K. Bhavsar

ABSTRACT

Several over-the-counter (OTC) and prescription medicines could cause toxic liver disease. OTC pain relievers: Acetaminophen. Aspirin, Nonsteroidal anti-inflammatory drugs (NSAIDs), ibuprofen, and naproxen sodium can cause harmful effect on liver if you take too much of the drug or take it with alcohol. Liver diseases are a major health problem in universal the various drugs that are responsible for the liver disease, including viral hepatitis, HIV, hemochromatosis, fibrosis, cirrhocis, obesity with the consequent non-alcoholic fatty liver, life-threatening chronic alcohol consumption, immune and cholestatic disorders, inherited metabolic disorders, numerous medications, schistosomiasis etc. Making it necessary to developed new molecules that help to treat or prevent the diseases. Correct prediction of the possible hepatotoxic nature of novel pharmaceuticals remains highly challenging. Therefore, it is essential to know in vitro models and in vivo model which causes the liver toxicity. It is also necessary to Screen out medicinal plants for their antioxidant potential.

Keywords: hemochromatosis, schistosomiasis, fatty liver, antioxidant.