Abstract

ANTI-INFLAMMATORY ACTIVITY OF LEPIDAGATHIS CRISTATA ROOT EXTRACTS

Vijaya Narasimha Reddy Peddireddy, Aravinda Reddy Purma*, Narothvam ReddyKavalakuntla, Rajendra Channa

ABSTRACT

The Lepidigathis cristata Wlld is belong to the family Acanthecae. In the present study the Anti-inflammatory activity ofroot extracts were performed. The methanol, ethyl acetate, chloroform extracts were prepared by soxhlet extraction method and were used for Antiinflammatory activity in two dose level that is 200 and 400 mg/kg body weight in two screening methods, one is carrageenan induced paw edema method (n=5), another is Formalin induced paw edema method (n=5) and the root chloroform extracts wereshowed maximum activity in both models with 43.4 and 29.7%of protection at 120 and 60 min intervals at the dose of 400mg/kg body weight.

Keywords: Lepidigathis cristata, Anti-inflammatory, carrageenan, Formalin, Methanol, Ethyl acetate, Chloroform. Root extracts.