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DESIGN AND EVALUATION OF FLUBIPROFEN ORODISPERSIBLE TABLETS USING CO-PROCESSED SUPERDISINTEGRANTS
V. Rajesh Babu* and Khaja Pasha
ABSTRACT The main objective of this study was to formulate and evaluate flubiprofen orodispersible tablets using co-processed super-disintegrants in different ratios (1:1, 1:2, 1:3, 3:1, 2:1), physical mixture of crospovidone and SSG and a control formulation (without superdisintegrnats) by direct compression method. The prepared formulations were evaluated for the pre compression parameters and all the formulations were found to possess good flow properties. The prepared tablets were evaluated for post compression parameters for hardness, friability, drug content uniformity, wetting time, water absorption ratio, in vitro dispersion time and dissolution studies. Among all the formulations FBP4 containing co-processed super-disintegrant (crospovidone: SSG, 3:1 ratio) with the concentration of 8% w/w produced less in vitro dispersion time (sec), water absorption ratio (99.31±1.15%), disintegration time (sec), wetting time (12.47±1.29 sec sec) and higher drug release rate (99%) in 30 minutes. Short-term stability studies on the promising formulations indicated that there are no significant changes in drug content and in vitro dispersion time. IR-spectroscopic studies indicated that there are no drug–excipient interactions. Keywords: flubiprofen, co-processed super-disintegrants, wetting time, water absorption ratio. [Download Article] [Download Certifiate] |