Abstract

PREPARATION AND EVALUATION OF DICLOFENAC SODIUM CUBOSOMES FOR PERCUTANEOUS ADMINISTRATION

Yallappamaharaj R. Hundekar*, Dr. J. K. Saboji,S. M. Patil, Dr. B. K. Nanjwade

ABSTRACT

The purpose of this research was to prepare and evaluate a cubosomes of diclofenac sodium, a non-steroidal anti-inflammatory drug (NSAID) by using different ratios of monoglyceride and polymer by top-down technique accompanied by homogenization. Nine formulations of diclofenac sodium cubosomes were prepared by using GMO as lipid emulsifier and Poloxamer 407 (P-407) as polymer in varying concentration and P-407 was also used as permeation enhancer and stabilizer. A number of NSAIDs have been developed for the treatment of generalized muscle and joint pain. Unfortunately these medicaments have major side effects caused by systemic administration. Furthermore, poor aqueous solubility of diclofenac sodium limits its formulation as topical dosage form. Therefore, an improved diclofenac sodium formulation with high degree of permeation could be useful in pain and inflammation. Transdermal delivery of diclofenac sodium alleviates the side effects caused by systemic administration. Transdermal delivery will also allow the drug to be delivered from cubosomes precisely into the body at the specific area of pain and at a controlled release manner due to its less viscosity.

Keywords: NSAIDs,Poloxamer 407, top-down technique, cubosomes, and vesicular drug delivery system.