Abstract

A REVIEW ON SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM CONTAINING DRUGS OF NATURAL ORIGIN

Heena Farooqui* and Prashant Upadhyay

ABSTRACT

The aim of this review is to study the development of Self Nano Emulsifying Drug Delivery System (SNEDDS) loaded with drugs of natural origin like Phytoconstiuents, Proteins, Enzymes and Biosimilars the drugs of biotechnological origin. It’s a boon in pharmaceutical field when nanotechnology combines with natural drugs because nanocarriers might be able to increase the bioavailability, potentiate the plant extracts therapeutic effect and reduce the required dose, side effects. Lipid based nano carriers such as SNEDDS is manufactured to improve the solubility of poorly and low water soluble drugs or drugs that come under Biopharmaceutical classification system (BCS) class II and class IV. SNEDDS is mainly an isotropic mixture of oil, surfactant and co-surfactant and drug molecule which suddenly form oil in water nanoemulsion of size ranges 50-100 nm in efficient mixing. Various pseudoternary phase diagrams are constructed to identify the nano-emulsification region.

Keywords: Poor Solubility, SNEDDS, BCS, Nanotechnology, Natural Origins.