Abstract

ASSOCIATION BETWEEN IRON PROFILE AND HEPATITIS B VIRAL LOAD IN SUDANESE PATIENTS

Alaa Hanafi Mekki* and Salma Elmalieh Abdalla

ABSTRACT

Introduction: Hepatitis B Virus infection is a major global public health problem, Chronic hepatitis B virus (HBV) infection affects 240 million people worldwide and can lead to chronic liver diseases including chronic hepatitis B (CHB), cirrhosis, and hepatocellular carcinoma (HCC). The aim of this study to determine the iron parameters level among Sudanese patients with hepatitis B virus infection to find association between the iron parameter level and virus activity. Methods: case control study was conducted in 120 individuals, 60 samples with HBV infection and 60 normal healthy subjects, simple random sampling technique was used to select the participant fulfilling the inclusion criteria from Elriyada medical laboratory Khartoum state, the data, was analyzed by SPSS version 23, independent samples T tests were used on numerical data to look at comparing mean of iron profile between case and control and one way ANOVA were used to compare mean of iron profile between different viral load activity in case group also person correlation to correlate between ALT and viral load level. All statistical results were performed under Decision rule at 0.05 with decision to reject the null hypothesis whenever p-value was less than 0.05. Results: the mean of serum iron was significant lower in cases group (86.3±36) when compared with control group(129 ±49) the mean of TIBC were significant lower in study group(212.6±56) when compared with control group(374±46), in addition; the mean of ferritin is also significantly high in cases group(241.6±161) when compared with controls group(86.6±13), no significant difference in transferrin between case and control. When comparing the iron profile in case group between different viral load found that significantly decreased in mean of serum iron in patients with high viral load(82±26) when compared with low(87 ±43)and very low (98±23) also there is significant decreased in mean of TIBC in patient with high viral load(193±35) when compared with low(205±45) and very low (223±65) .ferritin level was increased in high viral load (212±54)when comparing with low(198±54) and very low(161±61) viral load ranges. Also significant negative correlation was found between ALT and viral load level (-.515). Conclusion: From this study, we concluded that, Iron metabolism disorders can occur in patients with HBV infection. Also the serum markers of iron metabolism disorders vary in different level of HBV-activity levels.

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