Abstract

FORMULATION AND IN-VITRO EVALUATION OF HYDRODYNAMICALLY BALANCED SYSTEM FOR CIPROFLOXACIN HCL DELIVERY

Aditya Sharma*, Amarpal Singh, Arvind Kumar, Mayur Porwal and Vaibhav Rastogi

ABSTRACT

Sustained release gastro retentive drug delivery systems enable delayed and ceaseless contribution of the medication to the upper pieces of the gastrointestinal tract and improve the bioavailability of drugs that are portrayed by narrow therapeutics window. Present examination depicts an impact of Medium Molecular Weight Chitosan and High Molecular Weight Chitosan in blend with Hydrophilic HPMC K4M for continued delivery of water soluble Ciprofloxacin HCl by gelation of polymer lattices. Different plans were set up by physical mixing of Ciprofloxacin HCl and polymer(s) in fluctuating proportion followed by embodiment into hard gelatin cases. Every one of the definitions aside from F1 stayed light in 0.1N HCl (1.2 pH) all through the investigation. Impact of Chitosan on drug release was additionally explored and it was discovered that the drug release was altogether unique in contrast with F1 which contain HPMC K4M just (P>1.7521). It was additionally seen that Chitosan has shaped polyelectrolyte complex (PEC) with HPMC K4M in-situ during the gelation of HBS preparations in 0.1 M HCl. Our outcomes recommended that Medium Molecular Weight Chitosan and High Molecular Weight Chitosan with HPMC K4M is an incredible material for stomach explicit sustained drug delivery of Ciprofloxacin HCl from hydrodynamically adjusted single unit capsules.

Keywords: Gastroretentive, Ciprofloxacin HCl, Hydrodynamically balanced system, Chitosan, HPMC K4M.