Abstract

FORMULATION AND EVALUATION OF IN-SITU GEL OF SECNIDAZOLE FOR PERIODONTITIS

Bimal Debbarma* and Shankaraiya M.

ABSTRACT

Purpose: The objective of the present study was to formulate and evaluate in-situ gel containing secnidadazole. Approach: In-situ gel was prepared by ion dependent method, using mucoadhesive polymers such as gellan gum, xanthan gum. The in-situ gel was evaluated for physicochemical characteristics such as surface pH, drug content, gel strength, viscosity and in- vitro release study. Results: The IR spectra showed no interaction between drug and polymer. Physicochemical characteristics of all the samples were found to be satisfactory. Gel strength increases with increasing content of gellam gum and xanthan gum. Gel strength, viscosity and percentage of drug release increased with higher proportions of gellan gum, xantham gum and mannitol. In -vitro drug release studies demonstrated slower release of drug in formulations with higher amount of gellan gum, xanthan gum and mannitol. The in-vitro drug release data of most formulations best fitted first order, higuchi and korsymere model. Conclusion: The present work was taken up to use the gel forming solution of an ion activated polymer, such as gellan gum and xanthan gum in order to develop a in-situ gel of secnidazole for periodontitis which can be expected to prove beneficial for overcoming the limitations of oral and parenteral administration routes.

Keywords: Buccal mucosa, Mucoadhesive, Secnidazole, Ion dependent method, Gellan gum, Xanthan gum.