Abstract

REVIEW OF VALSARTAN ANALYSIS METHODS FROM 2000 TO 2020

Ellie Satriani, Rina Desni Yetti, and Harrizul Rivai*

ABSTRACT

Valsartan is used as a hypertension therapy that reduces blood pressure by inhibiting the activity of angiotensin II only at the AT1 receptor, hence it is also called ARB (angiotensin receptor blockers). The pharmacological effect of this drug is similar to the pharmacological effect of ACE inhibitors (angiotensin-converting enzyme), which results in dilatation of arterioles and veins and inhibits aldosterone sessions thereby reducing blood pressure and decreasing salt retention and water. valsartan is used as a hypertension therapy that reduces blood pressure by inhibiting the activity of angiotensin II only at the AT1 receptor, hence it is also called ARB (angiotensin receptor blockers). The pharmacological effect of this drug is similar to the pharmacological effect of ACE inhibitors (angiotensin-converting enzyme), which results in dilatation of arterioles and veins and inhibits aldosterone sessions thereby reducing blood pressure and decreasing salt retention and water. Angiotensin II type 1 receptor antagonists have been widely used in Indonesia for the treatment of various disorders such as hypertension, heart failure, myocardial infarction, and diabetic nephropathy. Over the years, various analytic methods have been developed. This review focuses on the latest developments in analytical techniques for estimating valsartan alone or in combination with other drugs in various biological media such as human plasma and urine. This review provides some insight into the analytical methods of UV spectroscopy, high-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (UPLC), high-performance thin-layer chromatography (HPTLC). which is used for the determination of valsartan both single and combination.

Keywords: Valsartan, spectrophotometry, potentiometric, HPLC, TLC, UPLC, voltammetry.