Abstract

BIOEQUIVALENCE STUDY OF TWO ORAL OXYTETRACYCLINE FORMULATIONS (HYPERSOL® AND OXILARG®) IN LAYING HENS

Ashraf Elkomy and Mohamed Aboubakr*

ABSTRACT

The present study was designed to assess the comparative bio-equivalence of Hypersol® and Oxilarg® in healthy laying hens after oral administration of both products in a dose of 20 mg oxytetracycline base/kg.b.wt. Twenty four laying hens were divided into two groups. The first group was designed to study the pharmacokinetics of Hypersol®, while the 2nd group was designed to study the pharmacokinetics of Oxilarg®. Each laying hen in both groups was orally administered with 20 mg oxytetracycline base/kg.b.wt. Blood samples were obtained from the wing vein and collected immediately before and at 0.08, 0.16, 0.25, 0.5, 1, 2, 4, 6, 8, 12 and 24 hours after a single oral administration. The disposition kinetics of Hypersol® and Oxilarg® following oral administration of 20 mg oxytetracycline base/kg.b.wt, revealed that the maximum blood concentration of oxytetracycline [Cmax] were 3.44 and 3.30 μg/ml and attained at [tmax] of 0.99 and 0.97 hours, respectively. In conclusion: Oxilarg® is bioequivalent to Hypersol® since the ratios of Cmax, AUC0-24 and AUC0-∞ (T/R) was 0.95, 0.94 and 0.93 respectively. These are within the bioequivalence acceptance range. Oxilarg® and Hypersol® are therefore bioequivalent and interchangeable.

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