Abstract

A REVIEW ON DESIGN & EVALUATION OF FLOATING BEADS OF ANTI-ULCER DRUG (ESOMEPRAZOLE)

Pratibha*, Monika Setia and Dr. Hariom Sharma

ABSTRACT

This article is about the investigation of formulation and evaluation of floating beads of an anti-ulcer drug. Sodium alginate, a polysaccharide forms a bio-adhesive and a stable gel with various properties such as Ca2 + which has enabled continuous drug release. It has been found that various materials are used like Esomerpazole, Sodium alginate, etc. Beads with synthesis of natural polymers such as sodium alginate and Xanthan gum with sodium bicarbonate as a gas-forming agent is organized. The technique, Fourier-transform infrared spectroscopy (FTIR) used for the compatibility checking. The characterization of bead helps in determining the particle size, percentage drug entrapment efficiency, in-vitro buoyancy and drug release. The size of main particle after formulation is specifying by optical microscopic studies, generally these sizes are in μm (micrometer). The Percentage of drug entrapment lies between 50-80% and buoyancy lies between 80-90%. The in-vitro drug results are also important to analyze the other parameter result. Furthermore this method involves some improvement in the drug delivery system of floating beads of anti-ulcer drug.

Keywords: floating beads, anti ulcer drug, Esomerpazole, bio-adhesive.