Abstract

A REVIEW: TRIAZOLE GOOD ANTI-MYCOBACTERIAL AGENT

Birendra Shrivastava, Gajanan Bhagwat*, Rajesh Patil and Sampat Navale

ABSTRACT

Tuberculosis (TB) is an ancient chronic infectious disease caused mainly by pathogen Mycobacterium tuberculosis (Mtb). According to the latest world health organization (WHO) report there were 8.7 million TB cases, including 1.1 million cases among people with HIV. In 2011 alone 1.4 million people died because of TB, including half a million are women and 430,000 people co-infected with HIV. Additionally, the evolution of its new virulent forms like multi drug resistant tuberculosis (MDR-TB) and extremely drug resistant tuberculosis (XDR-TB) has become a major threat to human kind. Out of new TB cases nearly 1.4 million people were reported HIV infected. The worst scenario is mortality with estimate of nearly 1.4 million deaths due to TB in 2015. Therefore, the discovery and development of effective anti-tuberculosis drugs with novel mechanism of action have become an insistent task for infectious diseases research programs. The literature reveals that, heterocyclic moieties have drawn attention of the chemists, pharmacologists, microbiologists and other researchers owing to its indomitable biological potential as anti-infective agents. Among heterocyclic compounds, triazole (1,2,3-triazole/1,2,4- triazole) nucleus is one of the most important and well-known heterocycles, which is a common and integral feature of a variety of natural products and medicinal agents. Triazole core is considered as a privileged structure in medicinal chemistry, are widely used as “parental” compounds to synthesize molecules with medical benefits, especially with infection related activities. In the present review, we have collated published reports on this versatile core to provide an insight so that its complete therapeutic potential can be utilized for the treatment of tuberculosis. This review also explores triazole as a potential targeted core moiety against tuberculosis and various research ongoing worldwide. It is hoped that, this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic triazole-based anti-tuberculosis drugs.

Keywords: Triazole; 1,2,3-triazole,1,2,4- triazole.