Abstract

FORMULATION AND EVALUATION OF TOPICAL HERBAL RAINBOW GEL

Vyas Jigar, Patel Ayushi*, Patel Disha, Parikh Jahanvi, Mistree Rinku and Prajapati Krupali

ABSTRACT

Objective: The present investigation aims at development and evaluation of herbal rainbow gel using natural ingredients which gives therapeutic effect without any side effect. The name RAINBOW is given to this gel as it contains seven herbal drugs. Methods: The gels were prepared using Carbopol with addition to the natural honey and glycerin (softening agent), methyl-paraben (preservative) and required amount of neem water. Then Gel was adjusted to Ph 7. Prepared formulation was evaluated for physical appearance, pH, spreadability, viscosity and homogeneity, skin irritation on animal model (rabbit) and anti acne activity on human volunteers. ICH guidelines have followed for stability studies. Results: Results reveal that gel showed good appearance, homogeneity, and spread ability. Viscosity is ranging between 4200 and 4500 centipoises. All formulations have shown no skin irritation to animals. The prepared gel has successfully reduced number and size of pimples during two weeks study period. The gel was found useful in treatment of skin Rashes, edema and in skin cracks. The preparation was stable under normal storage conditions for 6 months.

Keywords: Herbal gel, cow dung, garlic, onion, aloe, honey, neem and rose water.