Abstract

PREPARATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE BILAYERED MATRIX TABLETS OF VALSARTAN

Rama Rao Tadikonda* and Srilatha Ade 

ABSTRACT

The purpose of the present investigation was to prepare sustained release bilayered matrix tablets (MF1 to MF7) of valsartan by direct compression method using Hydroxypropyl cellulose, Xanthan gum, guar gum and to evaluate for various tests such as thickness, hardness, weight variation, friability, drug content and in vitro drug release studies. All the physico-chemical parameters of matrix formulations of valsartan were found to be within limits and all the matrix formulations provided the drug release up to 24 hrs in a controlled manner without changing their physical integrity in dissolution medium. The drug release data of all the matrix tablets fit well to the Higuchi expression clearly indicating that the drug release mechanism was predominantly diffusion controlled. The diffusional exponent values obtained from korsmeyer’s plot(n

Keywords: Valsartan, Sustained release, Bilayered matrix tablets, HPC, Xanthan gum, Guar gum.