Abstract

ANTI-INFLAMMATORY ACTIVITIY OF NOVEL QUINAZOLINONE DERIVATIVES

Govind Nayak*, Amit Kumar Nayak and A. K. Singhai

ABSTRACT

In the present work, nine novel 2-Substutied Phenyl-3-Phenyl Amino- Quinolin-4(3H)-One Derivatives [a-c] were synthesized by condensation between substituted quinazolinones and aryl hydrazine in the presence of glacial acetic acid. The structures of the synthesized compounds were characterized on the basis of IR, 1HNMR and Mass spectral data. All the synthesized compounds are screened for their anti-inflammatory activity by paw edema method, Indomethacin is employed as a reference standard. From the results it is concluded that, compounds 2a2, 2b2, 2b3, 2c1, 2c3, exhibited potent, rest of compounds exhibited moderate anti-inflammatory activity.

Keywords: Quinazolinone, Aryl hydrazine, Paw edema method and Anti-inflammatory activity.