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FORMULATION AND EVALUATION OF CARVEDILOL BUCCAL PATCHES: IN VITRO CHARACTERIZATION
Sai Priya R., Rajaguru R., Harish R., Venkatesh N. and Rama B.*
ABSTRACT The present investigation is concered with formulation and evaluation of mucoadhesive buccal patch containing antihypertension drug. Buccal patches for the delivery of carvedilol using combination of hydroxypropylmethylcellulose[HPMC] K15M, ethyl cellulose, propylene glycol, dichloromethane and ethanol in various proportions and combinations were fabricated by solvent casting technique. Variousphysic mechanical parameters like thickness, tensile strength, folding endurance, drug content, moisture content. The values for these were practically acceptable. Keywords: Carvedilol; buccal delivery; buccal patches; controlled delivery. [Download Article] [Download Certifiate] |