Abstract

A REVIEW STUDY ON NEW VALIDATED METHODS FOR DETERMINATION OF NAPROXEN AND PANTOPRAZOLE IN CAPSULE DOSAGE FORM

M. Bala Krishna*, B. Navya Durga and K. Padmalatha

ABSTRACT

Naproxen is a nonsteroidal anti-inflammatory drug, pantoprazole is a proton pump inhibitor. According to the World health statistics 2019 reports., increased blood pressure affects 1.13 billion people worldwide. The administration of anti-hypertensive drug and the combined use of naproxen and pantoprazole drugs have markedly reduced the blood pressure levels in patients. Based on the evidence of the combination drug which have been tested we decided to go on with naproxen and pantoprazole combination for validation. The primary goal of this article is to reduce the blood pressure levels, morbidity, mortality, improve quality of life, restore and preserve its immunological function. so according to that ideology some of the analytical methods like RP-HPLC, ultra violet spectroscopy, spectrophotometric and difference spectrophotometric methods are taken in to consideration which are ideal for analysis of combined drugs simultaneously.

Keywords: Naproxen and pantoprazole, high performance liquid chromatography, ultra violet spectroscopy, spectrophotometry.