Abstract

A REVIEW ON ORAL CONTROLLED DRUG DELIVERY SYSTEM: A MODERN FORMULATION APPROACH

Kajal L. Bisane*, Rahul H. Kasliwal, Yogesh N. Gholse, Pranali R. Gajbhiye, Karishma D. Kamde and Dinesh R. Chaple

ABSTRACT

Controlled-release (CR) formulations have been introduced into drug therapy with two main purposes, to reduce the number of single dose per day improving patient compliance of treatment and to decrease the fluctuations of plasma levels, in order to obtain better therapeutic efficacy and lower toxicity. The basic goal of therapy is to achieve a steady state blood level that is therapeutically effective and non-toxic for an extended period of time. The design of proper dosage regimens is an important element in accomplishing this goal. Controlled release, extended action, timed release, depot and respiratory dosage forms are terms used to identify drug delivery systems that are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. In the case of orally administered dosage forms, the period is measured in hours and critically depends on the residence time of the dosage form in the gastrointestinal tract. Controlled release also denoted systems which can provide some control whether this is of a temporal or spatial nature or both for drug release in the body. The system attempts to control drug concentrations in the target tissues or cells. Prolonged or sustained release systems only prolonged therapeutic blood or tissue levels of the drug for an extended period of time.

Keywords: Oral controlled release drug delivery system, matrix system, factors influencing oral CRDDS, Current and future development.