Abstract

IMPORTANCE OF CHIRALITY IN EFFECT OF ANAESTHETIC ACTIVITY: A REVIEW

Akshay S. Kasabe*, Mayur S. Bhosale and Sagar D. Magar

ABSTRACT

There is currently away from of a pattern inside the pharmaceutical business towards the occasion of chiral drugs. The numerous molecules can exist as right-handed and left-handed structures that are non-superimposable perfect representations of each other. They are called enantiomers or substances of opposite shape. Such substances additionally are called to be chiral compound (Greek chiros signifying 'handness'). The important good thing about chiral technology lies in its application within the explore for novel chemical lead compound in drug discovery and its appropriate formulation. In anaesthesia practice about quite half of compound is that the chiral compound most of the drugs available in market are in racemates or mixtures of two or more isomers. Out of those just one isomers shows anaesthetics activity and other enantiomers might not or they need other therapeutic activity. The difference in physicochemical properties may be arising from the various isomers, which can have direct respect to biological activity. These differences affect drug metabolism, absorption, excretion, serum protein binding. This review paper gives a quick idea about importance of chirality in anaesthesia and a few important example of anesthetic drug and it is pharmacokinetic and pharmacodynamics aspects of chirality.

Keywords: Chiral, enantiomers, isomers, anaesthetics drug, Chirality.