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DESIGN AND DEVELOPMENT OF ORODISPERSIBLE TABLETS OF TADALAFIL USING NOVEL SUPERDISINTEGRANTS
Mayur H. Patil*, Dr Surajj Sarode, Dr. P. V. Jain, Prof. B. S. Sathe, B. V. Jain, Dr. G.P. Vadnere
ABSTRACT The present work aimed at preparing oro-dispersible tablets of Tadalafil with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. The tablets of tadalafil was prepared by using superdisintegrants like sodium starch glycolate, Indion 234s, Indion 234 as an ion exchange resins by direct compression method. The formulated fast dissolving tablets were evaluated for physical characteristics such as Hardness, thickness ,uniformity of weight, drug content uniformity, Invitro disintegration and invitro dissolution .The formulations were subjected to disintegration, In-vitro drug release tests. The FTIR and DSC studies revealed that no physicochemical interaction between excipients and drug. Fast dissolving tablets of tadalafil containing combination of SSG and Indion 234s as superdisintegrant showed (94.33%) drug release within 10min. Percentage content uniformity (99.20%). Fast dissolving tablets of Tadalafil can be considered suitable for clinical use in the treatment of Erectile Dysfunctioning. Keywords: Tadalafil , Indion 234, Indion 234s, Direct comprssion method. [Download Article] [Download Certifiate] |