Abstract

IN-SILICO DOCKING ANALYSIS OF BETA LACTAMASE FROM KLEBSIELLA PNEUMONIAE WITH VARIOUS INHIBITORS.

Archana Moon*, Mohd Vashid Ansari, Anjali Wanjari, Bahuwarna Balpande, Dipali Simoniya and Kalyani Kalkar

ABSTRACT

The Urinary Tract Infection (UTI) is a prevalent disease whose misdiagnosis may lead to kidney disease and even pyelonephritis. Klebsiella pneumoniae is one of the most important causative pathogens of UTIs. Penicillin derivatives and Cephalosporins are the commonly prescribed antibiotics for UTI’s. Beta-lactamases are a large family of hydrolases, which catalyse the hydrolysis of the amide bond in the β-lactam ring of Penicillin and Cephalosporin. The hydrolysis product, Penicilloic Acid or Cephalosporoic Acid, is biologically inactive. Drug resistance to therapeutic antibiotics pose a challenge for the treatment of infectious diseases. In this study, in silico docking of various ligands/inhibitors to the Beta-lactamases has been performed by using Autodock Suite.

Keywords: Urinary Tract infections (UTI), AmpC & Oxa Beta-lactamase, Multi Drug Resistant (MDR), Docking.