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FORMULATION AND EVALUATION OF PULSINCAP DRUG DELIVERY SYSTEM OF NICORANDIL
*A. Sambasivarao, M.S, Ph.D, T. Jyotshna, S. K. Nishma, P. Lakshmi, Y. Shashank
ABSTRACT The present study was aimed to develop the formulation of pulsincap drug delivery system of Nicorandil. In this study Nicorandil immediate release granules were prepared by wet granulation method. F9 was selected as a better formulation to do the further process. In this study 100mg of hydrogel plug was prepared using HPMC K200M by wet granulation method using 5%w/v PVP K30 solution. Plug 3 was selected as a better formulation when compared to other formulations. FTIR studies has shown no interaction between polymer and drug. Cross-linked gelatine capsule were evaluated and confirmed that 24 hrs formaldehyde treatment was sufficient. 100mg hydrogel plug was optimized. The results indicated that drug content was uniform. In-vitro release studies revealed that increasing the polymer content resulted in sustained release. Value of n in Korsmeyer-Peppas Equation is greater than 0.89 hence, formulation were follows swelling controlled super case II transport. Keywords: Pulsincap, Nicorandil, HPMC K200M. [Download Article] [Download Certifiate] |