Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF NIMODIPINE USING DIFFERENT SUPER DISINTEGRANTS

Sanjiv Kumar Gupta* and Sunil Kumar*

ABSTRACT

In present study has been made for the development and evaluation of Fast dissolving tablets of Nimodipine prepared by using super disintegrants like crosspovidone, cross caramellose sodium and sodium starch glycolate by direct compression method. Effect of different super disintegrants on disintegration behavior of tablets was evaluated. All the formulations were evaluated for pre compression like angle of repose carr,s index & post compression parameters hardness, weight variation, wetting time and friability, invitro dissolution etc. Wetting time of formulations containing crosscarmellose sodium was least and tablets showed fast disintegration. Of the nine formulations studied F9 showed short dispersion time with maximum drug release 99.95% in 30Mins. The use of super disintegrant crosspovidone at concentration of 18% given the better release of drug when compared to other superdisintegrants. The proposed Fast dissolving formulation possessed ideal and reproducible characteristics of disintegration time and drug release profile.

Keywords: Nimodipine, In-Vitro Evaluation, Fast dissolving Tablets, wetting time.