Abstract

IN-SITU GEL DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF PERIODONTITIS

Sravani B.*, Sravani E., Keerthi K., Taruni T., Sandhya Rani B., Priyanka P. and Padmalatha K.

ABSTRACT

Periodontitis is an inflammatory disease characterized by progressive destruction of periodontal soft and hard plaque tissues leading to permanent tooth loss. The incidence of these diseases can be reduced by mechanical plaque removal or scaling and root planning (SRP) along with systemic and locally delivered antimicrobial agents or statins. In-situ gels are the drug delivery systems that are in solution form before administration in the body, but once administered in to the body undergoes gelation in-situ to form gel. Mechanisms involved in in-situ gel formation are solvent exchange, UV-irradiation, ionic cross-linkage, pH change, and temperature modulation. Polymers exhibit sol-gel phase transition and thus trigger drug release in response to external stimuli. The polymers used must be biocompatible, adhere properly to mucus, and exhibit pseudo plastic behavior. The main advantages of this route of drug administration is that it can deliver the active agents directly to the site of action at bactericidal concentration and it can facilitate prolong drug delivery.

Keywords: In situ gel, Periodontitis, Thermo-sensitive modulation, pH change and Statins.