Abstract

MULTI-TARGET DRUG DESIGN: AN EXAMPLE USING CATECHIN: REVIEW

Vedanti Yambal*, Omprakash Bende*, Niket Bajare*, Balaji Dhepe, Gajanan Nirmal, Kashinath Ughade

ABSTRACT

The pharmaceutical industry is increasingly joining chemoinformatics in the search for the development of new drugs to be used in the treatment of diseases. Singletarget drugs did not increase appreciably during the past decade. The investigation of genomic and proteomic finding multiple target for one drug has provide support for multitarget drug development. Multiple target models suggest that partial inhibition of a small number of targets can be more efficient than the complete inhibition of a single target. Success stories of multi-target drugs led us to suggest that systematic drug-design strategies should be directed against multiple targets. Catechins act on infection, neurodegeneration (such as Alzheimer‘s and Parkinson‘s diseases), and of malignancy (cancers) have complex multiple target diseases. Multitarget drug discovery has the power to identify potential modulators for these target. This review discusses the multi- target concept and its application in complex network.

Keywords: Multitarget, Genomic, Neurodegeneration, Cancer, Catechin.