Abstract

EFFECT OF BISOPROLOL AGAINST REDUCTION OF SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN HYPERTENSION WHITE RAT WITH HYPERCHOLESTEROLEMIA COMPLICATIONS

Miming Andika, Helmi Arifin and Harrizul Rivai*

ABSTRACT

Hypertension is a significant public health problem and is known as an independent risk factor for cardiovascular disease. People with hypertension also often experience complications such as hypercholesterolemia. Anti-hypertension beta-blockers are commonly used by people to treat high blood pressure and excessive heart rate. This study aims to look at the effect of bisoprolol on systolic and diastolic blood pressure. Also, this study aims to look at the impact of bisoprolol on the heart rate. In this study, all experimental animals were made into hypertension first. Then the group with complications of hypercholesterolemia was induced by feeding high fat and propylthiouracil (PTU). Blood cholesterol levels were measured using a clinic photometer. Systolic blood pressure, diastolic blood pressure, and heart rate were measured using non-invasive blood pressure (NIBP) blood pressure meter. Data from this study were analyzed with two-way ANOVA. The results showed that administration of bisoprolol at a dose of 2.5 mg, 5 mg, and 10 mg had a significant effect on reducing systolic blood pressure, diastolic blood pressure, and heart rate (p ˂ 0.05). The dose of 10 mg bisoprolol is the most effective in lowering systolic blood pressure, diastolic blood pressure, and heart rate.

Keywords: Hypertension, systole, diastole, heart rate, hypercholesterolemia, bisoprolol.