Abstract

SYNTHESIS, CHARACTERISATION AND ANTI-MICROBIAL ACTIVITY OF 1, 3, 4-THIADIAZOLE DERIVATIVES

Narsu Kumari Korrapati*, Nagendrababu Thirumalasetti, Shabana Shaik and Pravallika Segu

ABSTRACT

The need to design new compounds to deal with this resistance has become one of the most important areas of research today. Thiadiazole is a versatile moiety that exhibits a wide variety of biological activities. From the Review of literature it is known that 1, 3, 4-Thiadiazole are screened for enormous biological and pharmacological activities, still need for developing new derivatives at lead compounds level. Although there is availability of new technologies such as high-throughput screening, combinatorial technology and Computer aided drug design, for multitude of new safety requirements that have arisen has also brought unanticipated hurdles for the task of translating in vitro to in vivo studies. In the view of that novel Synthesis of 1,3,4 -Thiadiazole derivatives to explore Anti-microbial active compounds still draw continuous interest in molecular manipulations of active moieties with ensure to obtain drugs of high potency with low toxicity.

Keywords: 1, 3, 4-Thiadiazole, Anti-microbial activity, Escherichia coli.