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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT AND VALIDATION FOR ESTIMATION OF SOFOSBUVIR IN BULK AND PHARMACEUTICAL DOSAGE

Chennoju Vasudha*, Kunchanapalli Priyanka and Sujan Bathula

ABSTRACT

A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Sofosbuvir, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18(4.6×150mm, 5μ) column using a mixture of phosphate Buffer and Acetonitrile (45:55 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 260nm. The retention time of the Sofosbuvir was 3.166±0.02minrespectively. The method produce linear responses in the concentration range of 35-420μg/ml of Sofosbuvir. The method precision for the determination of assay was below2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

Keywords: Sofosbuvir, RP-HPLC, validation.

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