Abstract

A COMPARATIVE STUDY TO EVALUATE THE EFFECTS OF ANGIOTENSIN RECEPTOR BLOCKER AND CALCIUM CHANNEL BLOCKER COMBINATIONS ON RENAL FUNCTION AND LIPID PROFILE IN HYPERTENSIVE PATIENTS

Vinty Mary Johnson*, Allen George, Susmin Eapen, Jeenu Joseph, Dr. Sajan Ahmad Z MD, DM, DNB and Dr. Santhosh M. Mathews

ABSTRACT

Background: Hypertension is the most common cardiovascular disease and is associated with metabolic abnormalities like lipid profile dearrangement. It may also damage kidney. Antihypertensive drugs have an organ protective effect thereby it prevents cardiovascular complicationsAngiotensin receptor blocker-Calcium channel blocker combinations are one of the important therapy used in hypertensive patients. The effect of this combination on renal function, lipid profile and potassium was not well documented in most of the studies. So the study of this effect was undertaken in this study. Method: This prospective observational study selected 72 patients of greater than 18 years aof age based on inclusion criteria and excluded patient taking other drugs that affect our study parameters. 47 patients in this study were males and 25 were females. This 6 month study included a 3 month followup. Patient taking Telmisartan Cilnidipine combination and Telmisartan amlodipine combination were selected. Renal parameters like Creatinine, eGFR and potassium and lipid parameters like LDL,HDL,TGL,total cholesterol were noted before taking this combination and after 3 months of taking this combination. Results: This study showed that Telmisartan and Cilnidipine significantly (p=0.06, p˂0.10) reduced triglyceride than Telmisartan and Amlodipine combination. On renal parameters, Telmisartan and Cilnidipine combination significantly (p=0.07885, p˂0.10) increased eGFR than Telmisartan and amlodipine combination. Both combinations reduced Creatinine but on comparison this reduction was not significant (p=0.8108, p˂0.10). Total cholesterol, HDL, LDL and potassium did not show any significant change after 3 months. Conclusion: This study showed that Telmisartan Cilnidipine combination is more effective than Telmisartan amlodipine combination.

Keywords: Calcium channel blocker, Angiotensin receptor blocker, Estimated glomerular filtration rate, Telmisartan and Cilnidipine, Telmisartan and amlodipine.