Abstract

SPECTROPHOTOMETRIC ANALYSIS OF POORLY WATER SOLUBLE DRUG (ORNIDAZOLE) USING MIXED HYDROTROPY CONCEPT

Ketan Soni* and Dr. Kavita Sharma

ABSTRACT

Poor solubility is the main problem of maximum drugs in the case of analytical estimations. There are many drugs that are insoluble or poorly soluble in water. Many organic solvents such as carbon tetrachloride, methanol, acetone, benzene etc. are used in the spectrophotometric analysis of poorly water soluble drugs but these organic solvents are very expensive and toxic. If these organic solvents enter the body, they can cause many diseases like headache, eye irritation, nausea etc. Therefore these organic solvents need to be replaced with solvents which are cheap, eco friendly and easily available for analysis. With the help of hydrotropic solubilization and mixed hydrotropic solubilization technique the use of toxic organic solvents can be minimized. The compounds which are used to increase the solubilization of poorly soluble substances in aqueous solutions are called hydrotropes. They are soluble in water, cheap and easily available as well as non toxic. Examples of hydrotropes are urea, sodium citrate, sodium benzoate, sodium acetate, phenol etc. Mixed hydrotropic solubilisation technique is a phenomenon to enhance the solubility of poorly water soluble drugs. Blends of hydrotropic solution are used in this technique. It is new, safe, cost effective and eco friendly technique for the spectrophotometric analysis of poorly water soluble drugs. The main objective of the present study is to increase the solubility of ornidazole in water soluble solubilizer which are present in the blends. Proposed method is new, safe, economic, free from toxic organic solvents and accurate.

Keywords: Hydrotropes, Hydrotropy, Mixed hydrotropic solubilisation, Solubility, Spectrophotometric, Organic solvent.