Abstract

ANTIULCER ACTIVITY OF NERIUM INDICUM MILL.EXTRACTS IN ETHANOL INDUCED RATS

Shrinivas K. Sarje*, Rasale Snehal, Bhalerao Seema, Chavan Kunal and Deshmukh Shachi

ABSTRACT

Ulcers are lesions on the surface of the skin or a mucous membrane characterized by a superficial loss of tissue. Ulcers are most common on the skin of the lower extremities and in the gastrointestinal tract, although they may be encountered at almost any site. There are many types of ulcer such as mouth ulcer, esophagus ulcer, peptic ulcer, and genital ulcer, of these peptic ulcer is one of the world’s major gastrointestinal disorders. Nerium indicum Mill. is already traditionally as folk medicine to treat a number of illnesses. However, there is no scientific evidence in antiulcer activity of this plant. So, the present investigation explores the potential use of Nerium indicum Mill Stem extract as an antiulcer. Both the extracts were tested for their antiulcer property at a dose of 100 & 200 mg/kg against ethanol induced ulcer model in albino rats (Wistar strains) Ranitidine was used as reference standard. Both the extracts of Nerium indicum Mill. shows significant protection against ethanol induced ulcer model. Results shows protection by NIAqE (98.89%) & NIEE (97.42%) Against ethanol induced ulcer which are comparable to standard. The extract nor increased or decreased gastric volume, but increased in the pH of gastric juice was observed in ethanol method.

Keywords: Nerium indicum, Standardization, Antioxidant activity, Ethanol indused.