Abstract

A REVIEW STUDY ON CHALLENGES OF ION SPECTROPHOTOMETRY IN PHARMACEUTICAL ANALYSIS

M. Bala Krishna*, P. Navya Sri, M. Nafeesa Begum, V. Anusha, K. Katyayani, Dr. K. Padmalatha

ABSTRACT

Researches are still focused on the concept of ion pair formation their properties and applications in the various fields which was introduced in the year 1926, by Bjerrum. A pair of oppositely charged ions held together by coulomb attractions without formation of a covalent bond. Experimentally an ion pair behaves as one unit in determining conductivity, kinetic behaviour, osmotic properties, etc. investigation methods used are various, from classical conductometric measurements up-to-date methods such as spectrophotometry, chromatography and capillary electrophoresis. In case of pharmaceutical field, these ion pair are mostly used to develop the methods of separation identification and assay for the active substances in complex matrices, to obtain pharmaceutical formulations with controlled release and to explain the mechanism transport and action for certain drugs. This is an attempt to describe the new trends in spectrophotometry of ion pairs and their applications in the pharmaceutical field. The development of concept and types of ion-pairs are discussed first; further; examples of applications using molecular absorption, fluorimetry and resonance light scattering spectrophotometry are presented. Based on the literature data and the experience in the field, challenges and perspectives in the ion-pair spectrophotometry are also considered

Keywords: Ion-pair spectrophotometry, pharmaceuticals, UV-VIS absorption, fluorescence, resonance light scattering, resonance Rayleigh scattering.