Abstract

DESIGN OF CUCUMIN LOADED ALGINATE MICROBEADS ENHANCED FOR MUCOADHESIVE PROPERTY AND BIOAVALABILITY IN ALBINO RATS

*Shafura S., Babitha V., Harish K. H., Jayanthi C. and Hanumanthachar K. Joshi

ABSTRACT

Background: Curcumin contains 80% of the curcuminiods (4-5%) of the rhizomes of Curcumin longa L and saffron. This poly phenol regulates various targets through direct interaction or modulation of gene expression. Despite well documented clinical benefits in colon disorders and safety profile, curcumin has limited pharmaceutical role owing to reduced water solubility, instability in alkaline (

Keywords: Curumin, microbeads, alginate, tween80, span80, pharmacokinetics, mucoadhesiveness.