Abstract

FORMULATION AND CHARAC TERIZATION OF SOLID LIPID NANOPARTICLES OF QUETIAPINE FUMARATE TO IMPROVE SOLUBILITY

Maya Y. Gaikwad*, Amol S. Deshmukh and Vijay R. Mahajan

ABSTRACT

Quetiapine fumarate is an antipsychotic drug with plasma half-life 6 hr. and having poor oral bioavailability (9%) because of first pass metabolism. The aim of the present study was to develop an optimal SLN formulation of Quetiapine fumarate to improve solubility and oral bioavailability. Liquid dispersion of SLN were framed with Oleic acid as oil phase, Cremophor RH 40 and Tween 20 as surfactant and Transcutol P as co-surfactant after screening several vehicles. The prepared formulation was constructed by using phase diagram to optimize the system. Solidification of SLN was done by using spray drying technique using Aerosil 200 as solid carrier. The drug release study shows that the release of Quetiapine fumarate was enhanced in SLN formulation as compared to plain drug and marketed formulation. Stability study shows that there was no sign of change in drug content was observed.

Keywords: Pseudoternary phase diagram, Quetiapine fumarate, SLN, Oral bioavailability.