Abstract

COLON TARGETED DRUG DELIVERY SYSTEM

Nikhil Arun Shete*, Mohan R. S., Kotame R.N., Pawar V. V. and Gore S. J.

ABSTRACT

Colon targeted drug delivery system (CTDDS) delivered the drug local as well as systemic delivery of drug. The CTDDS is used for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of Insulin, protein and peptide drugs. To achieve successful CTDD (colon targeted drug delivery), a drug need to be protected from gastric environment (protect from degradation), release and absorption in upper portion of the GI tract and then to be ensured abrupt or controlled release in the proximal colon. This review is focused on the novel approaches in the colon targeted drug delivery, merits and demerits, clinical evaluation techniques of CTDDS.

Keywords: Colonic drug delivery, Drug targeting, pH dependent, gamma scintigraphy.