Abstract

FORMULATION AND EVALUATION OF EFFECT OF DIFFERENT SUPER-DISINTEGRANTS ON ORODISPERSIBLE TABLETS OF ALBENDAZOLE, MEBENDAZOLE AND IVERMECTIN

Muhammad Abbas Bhatti*, Musharraf Abbas Bhatti, Fatima Tariq, Hamza Zahid, Rabiya Yasin and Dr. Saeed ul Hassan

ABSTRACT

In the modern era, demand of orally disintegrating tablets (ODTs) has been increased due to rapid release and systemic availability of their components upon contact with oral cavity without swallowing. Moreover, ODTs are peffered by children, geriatrics, bed ridden and uncooperative patients. Albendazole, mebendazole and ivermectin are anti helminthics that produces its action by inhibiting microtubule and hence cause death of parasites. Moreover, Ivermectin performs its action by hyperpolarization and paralysis of parasites which ultimately lead to death of parasite. Orodispersible tablets can be prepared by using different methods such as freeze drying, sublimation, molding, spray drying, mass extrusion, phase transition, nanonization, fast dissolving films, direct compression, melt granulation, cotton candy process, wowtab technology, Flashtab technology. In the present research, orodispersible tablets were being prepared by melt and wet granulation methods and effect of different super-disintegrants like cross povidone, cross carmellose sodium and sodium starch glycolate was evaluated on orodispersible tablets of albendazole, mebandazole and ivermectin. Pre compression and post compression parameters such as Angle of repose, Hausner’s Ration, Carr’s compressibility index, and Disintegration time, dissolution time, stability studes respectively were being performed on prepared formulations i.e. T1-T9. It was found that results of all the formulations lie in official limits. Moreover, formulation T3 is optimum dosage form that has suitable mechanical strength, excellent disintegration time and release profile .i.e. 5 sec which release up to 90.30% drug in 15 minutes respectively.

Keywords: Orodispersible tablets, super-disintegrants, melt granulation, wet granulation.