Abstract

BRYOPHYTES FROM CERRADO-AMAZON TRANSITION REGION CAN ACTS ON BREAST CANCER CELLS

Muryllo Mendes Possamai*, Gabriel Triches Nunes*, Sarah Silva Machado, Francisco De Paula Athayde Filho, Katleyn Polizeli Galvão Silva, André Henrique Furtado Torres, Danny Laura Gomes FagundesTriches, Adenilda Cristina Honorio-França, Eduardo Luzía França and Joaquim Manoel Da Silva

ABSTRACT

Bryophytes are a heterogeneous groups of terrestrial plants with various biological activity. The uses of bryophytes by popular medicine for therapeutic have been understudied, because it is generally assumed that bryophytes never play a direct role in human life. The aims of this study was verify the possible effects MCF-7 cells and blood from volunteer donors were incubated with Bryophytes for 24 hours. The rheological parameters and the supernatant culture the superoxide dismutase concentration were evaluated. No difference was detected between blood flow curves and viscosity obtained for human Blood or MCF-7 cells when in presence of Bryophytes spp. In blood, the superoxide dismutase (SOD) levels, independently of treatment of Bryophytes spp. was similar. In general, MCF-7 cells showed higher SOD levels with values similar to the levels of blood. The lowest SOD levels were observed in the culture supernatant of MCF-7 cells incubated with Brypophyte spp. In the Blood and MCF-7 treated with Bryophytes spp. the viscosity was negatively correlated with CuZn-SOD. The viscosity of blood or MCF-7 without treatment of Bryophytes spp. showed no correlation with CuZn-SOD levels. In conclusion, Bryophytes spp. produced effects against human MCF-7 breast cancer cells. Bryophytes spp. hold great potential for novel therapies, though links with ethnopharmacology for treatment of breast cancer. However, new experimental and pre-clinical tests must be carried out to confirm the efficacy of this plant.

Keywords: MCF-7 cells, Superoxide dismutase, Medicinal Plants, Rheology.